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The painful truth about gout The 'disease of kings' now has more to do with poverty than privilege

Gout is not karma for the sin of greed. Credit: Historica Graphica Collection/Heritage Images/Getty Images

Gout is not karma for the sin of greed. Credit: Historica Graphica Collection/Heritage Images/Getty Images


December 15, 2020   5 mins

Disease is no democrat. As 2020 has demonstrated. This year has made us all part of a vast data-collection project that will, when computed, reveal Covid-19’s favourites and perfect victims, its disproportionate wrath. We already have the preliminary findings.

Black Britons and poor Britons have suffered the most. This could be a propensity of the Coronavirus, but it might simply be a function of the contemporary United Kingdom, where living in the richest areas of the country buys you almost 19 more years of life than if you lived in the most deprived. If the Victorian researcher Charles Booth were to rise from the grave to draw us some new poverty maps, he’d still need all those different coloured inks.

One ailment, though, maintains a reputation for discriminating against the wealthy. Gout makes big toes swell painfully and cartoonishly. It causes chalky nodules called tophi — often compared to crustacean eyes — to balloon from knees and knuckles. It hurts. (“Like walking on my eyeballs,” reported the Regency cleric and humourist Sydney Smith.) The condition occurs when excessive amounts of uric acid in the blood cause crystalline needles of salt to gather in the joints and surrounding tissues. Its raw materials are purines — chemical compounds thickly concentrated in seafood, meat and alcohol — which helps to explain why gout gained its status as “the disease of kings.”

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“Gout,” concluded Thomas Sydenham, one of the founders of British clinical medicine, “kills more rich men than poor, more wise than simple.”

Three centuries later, that’s no longer the case. The last big British study found that prevalence of gout in the population had increased by over 60% between 1997 and 2012. (Wales and the north-east of England were particularly afflicted.) In US, the “gout therapeutic market” is valued at $1847m, and a report released last month projected it might reach $3820m by 2027.

Thomas Sydenham might have looked at these figures and seen a strange and painful kind of social progress; a pathological levelling-up. In his day, only the wealthy could afford to surfeit on lampreys, pate and port. Perhaps, in 202o, cheap meat, cheap booze, the Iceland prawn ring and the two-metre long Aldi pig-in-a-blanket have made gout a disease to which anyone can aspire.

The history of gout is as much about culture and class and morals as medicine. It’s a deep and uncomfortable history. Papyri discovered in the 1910s showed that the Egyptians had identified the condition by 2640 BC. In the 5th century BC, the physician Hippocrates referred to it as “the walking disease”. The name by which we know it calls back to the humoral theories of human biology that persisted from Ancient Greece to the early modern period. It comes from the Latin gutta (“drop”), and was first recorded by the 13th century by the French historian Geoffroi de Villehardouin, who asserted that the crusader Hugh IV of Saint-Pol had expired at Constantinople in 1205 because too much fluid — black bile, yellow bile, or phlegm — had spilled down into his legs.

Despite such horrors, gout conferred a kind of blessing. It was rarely fatal, and its presence in the body was thought to keep other, more deadly conditions at bay. “It prevents other illnesses and prolongs life,” argued Horace Walpole, “Could I cure the gout, should not I have a fever, a palsy, or an apoplexy?”

Surprisingly, for a condition that can turn your joints into throbbing satsumas of flesh, it was even considered sexy. Gout talk added a frisson to Benjamin Franklin’s flirty correspondence with Anne Louise Brillon de Jouy, a married harpsichordist he met in Paris in 1777. Franklin teased Brillon that had they consummated their relationship, his feet might be less painful in the night. (“If the ladies at Passy had more of that Christian charity which I have so often recommended to you, in vain, I would not have the gout now.”) She responded with a poem proposing the opposite: a man with “a pretty Mistress” — or two, or three, of four — was more likely to suffer. Franklin’s reply was to stay up late writing a short two-handed comedy in which the personification of his condition, Madame Gout, visits him in his chamber, rather as Fortune visits Boethius in Consolations of Philosophy.

Novelists and politicians no longer feel the compulsion to turn their uric tortures into light literature. Despite the rise in cases, the discourse of gout has all but disappeared. And yet, the moral ideas that have circulated it since ancient times — its association with excess and indulgence — are still legible. They’re there, for instance, in Yorgos Lanthimos’s 2018 film The Favourite, in which the agonies suffered by Olivia Colman’s Queen Anne are attributable to her predilection for self-pity and stuffing herself with massive slices of cake. We see her engorged legs swaddled and smeared in therapeutic unguents. (We’re not told what these are, but one traditional remedy is advised: “Roast a fat old goose and stuff with chopped kittens, lard, incense, wax and flour of rye. This must all be eaten, and the dripping applied to the painful joints.”)

The outgoing Republican administration, though, should be given some credit for reviving gout as a moral metaphor — via the story of Paul Manafort, the disgraced chair of Trump’s 2016 election campaign. Manafort was convicted in August 2018 for lying his way to securing bank loans and evading taxes on the $16 million he earned as a lobbyist for pro-Russian politicians in Ukraine. His trial produced evidence of a fraud-funded life of eye-watering excess. His $15,000 ostrich-leather bomber jacket became a court exhibit. “The gluttony,” reflected the fashion critic of the Washington Post. “The indulgence. The preening bad taste.”

When he appeared for sentencing in October, he rolled into court in a wheelchair. His body was clad in a green prison jumpsuit labelled “ALEXANDRIA INMATE”, but his right foot was wrapped in bandages. His attorneys used his gout diagnosis as part of a plea for mercy. The judge, passing sentence the following March, was unmoved. “It is hard to overstate the number of lies and the amount of fraud and the extraordinary amount of money involved,” said US district judge Amy Berman Jackson. Manafort’s lies to Congress and to the American people, she observed, were perpetrated “not to support a family, but to sustain a lifestyle that was ostentatiously opulent and extravagantly lavish – more houses than a family can enjoy, more suits than one man can wear”.

Manafort sat in his wheelchair and listened in silence to the judgement. He wore a sober suit. His right foot remained bandaged. Its swollen condition became part of the story. Gout as an indicator of corruption? Gout as karma, perhaps?

Too easy. Too satisfying. Champagne and foie gras can exacerbate an attack of gout, but if Manafort is a typical case, his condition is probably genetic. People who live on nut loaf and tap water are not immune and know its nocturnal agonies. The rise in gout’s prevalence in the UK and the US can’t be mapped onto any growth in the sale of purine-rich luxuries. Something more complex is happening.

Obesity is rising. The population is ageing. There are more people alive today in gout’s high-risk groups than there were in the days of Sydenham and Walpole. Let the law punish Paul Manafort, not the cultural backstory of the uric crystals giving his foot the Little Mermaid treatment. And let it bring justice for those others, too, who are enduring illness associated not with privilege, but its opposite.


Matthew Sweet is a broadcaster and writer. His books include Inventing the Victorians and Operation Chaos: The Vietnam Deserters Who Fought the CIA, the Brainwashers and Themselves.

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jmskennedy9
jmskennedy9
3 years ago

Stupid article, assumes direct causation rather than correlation. I have treated hundreds of gout patients over my career and they come from all economic walks of life. Yes genetic, but flairs often behavioral. Diets and meds work to control most cases, some meds are cheap some aren’t.

Anna Tanneberger
Anna Tanneberger
3 years ago
Reply to  jmskennedy9

Agreed. I stupidly kept scrolling down to see if there’s a new insight somewhere. Or maybe someone’s discovered something about gout. Nothing. Just meanders and opines.

Martin Davis
MD
Martin Davis
3 years ago
Reply to  jmskennedy9

Yes. I got it several times in my mid 60s. Its inception coincided with a panic attack. After a couple of years, and a move into a stress-free retirement, no recurrence. My conclusion was that my body was yelling at me to slow down and take it easy. When I did, no more yelling.

Athena Jones
Athena Jones
3 years ago
Reply to  Martin Davis

Very wise. Symptoms are the language the body uses to speak to us and to seek to restore balance on all levels. We drug them into submission at our peril for that drives disease deeper. If we listen, take heed, hear them and act, then they have no need to speak further, or indeed, to ‘scream’ at us to listen.

Hardee Hodges
Hardee Hodges
3 years ago
Reply to  jmskennedy9

Remarkable how a inexpensive drug ColCrys turned expensive with a few manipulations, but only in the US. Elsewhere, it’s quite inexpensive.

Ocxl Ocxl
Ocxl Ocxl
3 years ago

Allopurinol- the gift of the gods. I have done everything in the past 35 years to escape gout. As a poor student and then health worker, then teacher I often wanted to live without gout drugs so went on regular health regimes, thinking if I lived without ANY of the foods which stimulate and attack I would be fine. I ran miles and swam loads. The longer I avoided those foods and the more healthy things I did the more painful it became. I wanted to control it by diet or celery seeds or no beer, but was not to be. So Allopurinol is my friend. ( I still swim and eat well and dont drink beer, but thats a choice because I am not in pain.) Happy days

Neil Papadeli
Neil Papadeli
3 years ago

Aldi do a 2 metre pig in a blanket? Hasty footsteps, door slam, engine revs, tyres screech…

No, not really.

William Gladstone
WG
William Gladstone
3 years ago

If gout were about corruption and opulence then wokedom would be full of painfully inflamed feet. Perhaps Meghan Markle would learn humility and Bill Gates perspective and Joe Biden not to be so creepy. Unfortunately that miracle disease is yet to exist.

Gout is nasty and as you say obesity is a factor so the lot named above by having a hand in convincing people that lockdowns are required probably have helped increase the prevalence of gout.

Kevin Ryan
Kevin Ryan
3 years ago

Gout is the fault of the woke ! It’s so blindingly obvious, now you point it out.

Paul Kelly
PK
Paul Kelly
3 years ago

Alopurinol for me also. Hardly an attack since I started taking it ?20? years ago. Only breakthrough attacks were when I developed a taste for Asparagus from a newly open farmers market. Stopped eating asparagus and not a problem since. I drink beer and eat all the other apparent trigger foods.

Advice from my doctor was that gout arises from a combination of genetic predisposition plus diet.

I did read one time that the suggestion that rich Georgian gentlemen were predisposed to gout because of a rich diet was better explained by a combination of age (rich lived longer that poor) and leaching of lead from lead crystal port decanters. I read now that increased lead exposure does indeed increase Uric acid level in blood.

Fraser Bailey
Fraser Bailey
3 years ago

This is the second article by a BBC type today and it is still dark outside. I threw out the TV 20 years ago to get away from BBC types.

I believe my father has a touch of gout despite having led a very abstemious life.

Albert Kensington
AK
Albert Kensington
3 years ago

I’m a bit reluctant to draw general conclusions when my gout attacks 10 years ago were triggered by an inordinate love of real ale. Apart from moderation what I found particularly effective was celery seed pills. Big Pharma chemicals as dished out by GP’s I found completely ineffective

Mike Feilden
Mike Feilden
3 years ago

Gout is a highly individual problem – in my case it was a reaction to medication prescribed for high blood pressure – a change of medication eliminated the gout but caused a reaction in my left leg similar to cellulitis – a further change of medication has left me gout free for several years – no amount of dietary tinkering had any effect whatsoever.

No Thanks
No Thanks
3 years ago
Reply to  Mike Feilden

Whats the medication that works for you Mike?

John Smethurst
John Smethurst
3 years ago
Reply to  No Thanks

Allopurinol. It’s the classic one pill a day treatment.

William Cameron
William Cameron
3 years ago
Reply to  John Smethurst

But you have to take it forever

Quentin Vole
Quentin Vole
3 years ago

Indeed, but allopurinol is very safe and very effective – millions of people (including me) have been taking it for decades. It’s also long out of patent, so pennies a tablet. It’s possible for some people to manage gout through diet, but elevated urate levels will still be present and can give rise to other medical problems.

Most gout is hereditary, caused by a mutation that restricts the body’s natural ability to eliminate uric acid – my maternal grandfather was a sufferer (and he was a riveter in NE England, port and grouse did not feature in his diet) and so is my brother. (Women may suffer from gout, but it’s unusual.)

Athena Jones
Athena Jones
3 years ago
Reply to  John Smethurst

The most powerful aspect of it is probably placebo. Medication for life is not cure and they all have toxic side effects. But, to each their own.

Karl Schuldes
Karl Schuldes
2 years ago
Reply to  Athena Jones

If you experience gout, you will take whatever they give you to avoid it again.

Mike Feilden
Mike Feilden
3 years ago
Reply to  No Thanks

I no longer get gout so I don’t take anything for it – I take perindopril for high blood pressure – no side effects from that

Mike Feilden
Mike Feilden
3 years ago
Reply to  No Thanks

I haven’t needed anything for gout since I started on Perindopril for my blood pressure – however drugs have different side effects for different people

Konstantin Kouzovnikov
Konstantin Kouzovnikov
3 years ago

A neglected research area is his opportunity to pontificate politically? Now that we know how far he can take us because of the gout I wonder where on earth he can take us because of, say, frequent farting? Thanks for taking us down the memory lane anyway!

Annette Kralendijk
Annette Kralendijk
3 years ago

If bad taste was a crime, you’d have to,lock up three quarters of Washington DC and the vast majority of parliament.

Key risk factors for gout include being male, over 65, and being of African American, Hispanic, Pacific Islander, or American Indian descent. Sounds like a huge chunk of the population of the US.

David George
David George
3 years ago

It’s very painful but the anti-inflammatories taken at the first sign nip it in the bud – works for me anyway. Drink plenty of water and you can get away with a bit of excess elsewhere.

William Cameron
WC
William Cameron
3 years ago

Strong Lager is very bad for Gout . As is red meat . A big plate of Steak Tartare and a few pints of strong lager (or similar) in a warm climate and you will soon get gout. Funnily enough the drink of choice for the unfortunates referred to here is – strong lager.

Riccardo Tomlinson
Riccardo Tomlinson
3 years ago

There are two broad groups of gout sufferers. One is mainly weight and lifestyle related, and is occasional. This can be managed by the right choices. The other is the relentless genetic disposition.

Either way, take the Allopurinol, people. It’s the most benign drug. No side effects and in the long term extremely effective. It’s changed my life. Do not delay.

Athena Jones
Athena Jones
3 years ago

People on average also have poorer health because of the many medications, vaccinations, chemically laden food and cleaning and body products, over-processed nutrient-poor food, bad sleep from rooms full of electronic equipment and usually sleeping on non-breathing synthetic bedding and wearing non-breathing synthetic clothes.

All of which is a testament to the resilience of the human condition. However, good health will never come from a pill or a needle and holistic medical modalities and healthy lifestyle practices are the best options still. Modern medicine still sells snake-oil, just in more sophisticated form.

No condition, including gout, is every solely physical in origin and unless the many contributing factors like emotional, mental, spiritual, environmental, circumstantial are addressed there will never be cure.

Caitlin McDonald
Caitlin McDonald
3 years ago
Reply to  Athena Jones

chemically laden food

All food IS chemicals. Water is chemicals. You are chemicals.

Where do you get the literature that you trust as the truth? I have met many anti-science people and they can never tell me why they trust the sources they trust.